Zymo Research Unveils PureRec DSN: The Most Selective Duplex-Specific Nuclease

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IRVINE, Calif., June 4, 2024 /PRNewswire/ — Zymo Research, a leader in biotechnological advancement has launched a new nuclease called PureRec Duplex-Specific Nuclease (DSN) that selectively digests double stranded DNA (dsDNA). This new PureRec DSN promises unparalleled specificity in targeting duplex DNA, unlocking a variety of potential applications.

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DSN selectively digests dsDNA and DNA in DNA-RNA hybrids, while sparing single-stranded DNA (ssDNA) and RNA. Because of its selectivity, it has proven to be useful in a broad range of research fields and bioscience industries. For example, it can effectively reduce abundant rRNA transcripts, enhancing NGS libraries. Additionally, it has been utilized in the development of high-sensitivity microRNA (miRNA) biosensors.

Traditionally, DSN is sourced from king crab, which is challenging to purify. This poses inherent contamination risks and batch-to-batch consistency issues. The compromised purity may result in non-specific activity towards ssDNA and RNA, thereby jeopardizing downstream applications. Recognizing these challenges, Zymo Research engineered PureRec DSN as an alternative with superior purity and performance. Compared to other duplex DNases, PureRec DSN demonstrates the highest purity and selectivity for duplex DNA while preserving ssDNA and RNA. This is critical for applications like RNA-Seq library preparation, miRNA detection, SNP and biomarker detection. Additionally, the production process excludes any animal-derived raw materials, ensuring an animal-free product and minimizing the risk of introducing animal-derived contamination.

Developed and manufactured in Zymo Research’s state-of-the-art facility in California, PureRec DSN embodies a commitment to excellence, empowered by specialized expertise and cutting-edge protein engineering, expression, and bioprocessing technologies. PureRec DSN is setting a new standard for duplex DNases, expanding the possibilities for applications that require precise selectivity in dsDNA digestion, such as reduction of abundant rRNA transcripts, precise SNP detection, enhanced signal amplification, and improved miRNA detection. PureRec DSN unlocks unprecedented possibilities for researchers and industries worldwide.

For more information or bulk inquiries on Zymo Research’s recombinant PureRec DSN, please visit PureRec Duplex-Specific Nuclease.

About Zymo Research Corp.

Founded in 1994, Zymo Research is a privately-owned company with a strong focus on research and development, placing high value on innovation to create cutting-edge molecular tools tailored for the biotech sector. Guided by the motto “The Beauty of Science is to Make Things Simple,” Zymo Research is renowned for its innovative products, spanning epigenetics to DNA/RNA purification technologies. Expanding beyond its historical leadership in epigenetics, the company is now revolutionizing sample collection, microbiome application solutions, recombinant protein and enzyme production, and next-generation sequencing (NGS) services. Zymo Research’s commitment to simplicity and high quality is evident in their user-friendly solutions, reflecting their dedication to advancing scientific processes. Follow Zymo Research on Facebook, LinkedIn, X (Twitter), and Instagram for the latest updates on their contributions to the field of biotechnology.

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